Dopasomes: dopamine-mediated cross-linked lipid vesicles.

Authors

Keita Yamana, Kouki Fujihara, Miu Maeda, Tomoki Nishimura, Riku Kawasaki, Atsushi Ikeda

Published in

Journal of materials chemistry. B. Sep 23, 2025. Epub Sep 23, 2025.

Abstract

Liposomes offer significant advantages for drug delivery but are limited by poor stability, which hinders product development and therapeutic efficacy. In biological environments containing surfactant-like components such as serum proteins and bile salts, liposomes are susceptible to destabilization. In this study, we designed and synthesized dopamine-containing, self-polymerizing lipids that self-assemble into liposomal structures, termed as "dopasomes." Dopasomes retained their structural integrity even in the presence of Triton X-100 and enabled efficient intracellular delivery of doxorubicin hydrochloride.

PMID:
40985111
Bibliographic data and abstract were imported from PubMed on 23 Sep 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.