Comparison of Antibacterial Efficacy of Conventional Root Canal Irrigation System and Metronidazole, with and without Pro-agitator Tip System, in Primary Anterior Teeth: An In Vivo Study.

Authors

Aditi P Patil, Laxmi Lakade, Krishna Patil, Preetam Shah, Smita Patil, Rucha Davalbhakta

Published in

International journal of clinical pediatric dentistry. Volume 18. Issue 8. Pages 911-916. Epub Sep 04, 2025.

Abstract

The current study was designed to compare the antimicrobial efficacy of the conventional irrigation technique with sodium hypochlorite (NaOCl) and metronidazole (MTDZ) using a disposable syringe and pro-agitator tip system (PATS) against Enterococcus faecalis in primary anterior teeth.
About 42 children requiring pulpectomy in nonvital primary anterior teeth were divided into three groups. In the control group, teeth were irrigated with 3% NaOCl using a conventional needle irrigation (CNI) system. In experimental group I, 0.5% MTDZ and a CNI system were used, and in experimental group II, 0.5% MTDZ irrigant was used with the PATS. Samples were collected before and after cleaning and shaping of canals using paper points. The samples were incubated at 37°C for 24 hours on bile esculin agar, and colonies of Enterococcus species were counted.
Significant reduction in the percentage of Enterococcus species was found in the control group (88.38%) as compared to experimental groups I and II. Meanwhile, no significant difference was seen in the reduction of the species between experimental group I (38.78%) and experimental group II (53.52%).
NaOCl irrigation with a conventional needle showed better antibacterial efficacy against E. faecalis when compared to MTDZ with CNI and the PATS. No difference between MTDZ with CNI and with the PATS was seen.
About 3% NaOCl irrigant with CNI has shown antibacterial efficacy against E. faecalis as compared to 0.5% MTDZ with CNI and the PATS.
Patil AP, Lakade L, Patil K, et al. Comparison of Antibacterial Efficacy of Conventional Root Canal Irrigation System and Metronidazole, with and without Pro-agitator Tip System, in Primary Anterior Teeth: An In Vivo Study. Int J Clin Pediatr Dent 2025;18(8):911-916.

PMID:
40989971
Bibliographic data and abstract were imported from PubMed on 24 Sep 2025.

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