Authors
Wanying Zhao, Huanxin Xie, Weiqun Song, Lei Cao, Linlin Ye
Published in
Brain topography. Volume 38. Issue 6. Pages 72. Sep 27, 2025. Epub Sep 27, 2025.
Abstract
Unilateral neglect (UN) is a common post-stroke neurocognitive deficit linked to interhemispheric interactions, though mechanisms remain unclear. This study evaluated the 'bimodal balance recovery' model in UN, exploring its relationship with interhemispheric connectivity and proposing a stratification framework for patient categorization. Thirty stroke patients with UN and 15 healthy controls were recruited. Interhemispheric signal propagation (ISP) was assessed using transcranial magnetic stimulation-electroencephalography. UN severity was quantified using a battery of paper-and-pencil tasks, and overall patient functioning was evaluated using the Activities of Daily Living Scale, Fugl-Meyer Assessment, and Berg Balance Scale. Analyses of the Schenkenberg Line Bisection Test, Albert's Cancellation Task, and Ota's Cancellation Task indicated that quadratic models provided a better fit than linear regressions. A novel metric, the PenPCA Index, was derived using Principal Component Analysis (PCA) to assess the complex relationship between ISP and UN. This index demonstrated a bimodal relationship with ISP, effectively distinguishing between negative and positive correlations with the PenPCA Index. This study introduces the PenPCA Index, underscores the bimodal UN-ISP relationship, and offers a stratified assessment framework for stroke patients.
PMID:
41015628
Bibliographic data and abstract were imported from PubMed on 28 Sep 2025.
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