Nickel-Catalyzed C(sp³)-C(sp³) Coupling of Cyclopropanols via α-Bimetalloid Radicals: Access to γ-Carbonyl gem-Bis(boronates) and gem-Silylboronate Esters.

Authors

Linfei Zhu, Xueyu Zhang, Hui Wang

Published in

Organic letters. Sep 29, 2025. Epub Sep 29, 2025.

Abstract

Herein, we disclose an efficient nickel-catalyzed C(sp³)-C(sp³) coupling reaction of ambiphilic reagents with cyclopropanols, enabling direct access to a range of synthetically valuable γ-carbonyl gem-diboronates and γ-carbonyl gem-silylboronate esters in good yields. This method shows broad substrate scope and excellent functional group tolerance for cyclopropanols. Mechanistic studies indicate the involvement of α-bimetalloid radicals, and the resulting Bpin groups in products offer versatile handles for further derivatization.

PMID:
41021750
Bibliographic data and abstract were imported from PubMed on 30 Sep 2025.

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