Visible-Light-Excited Lewis Acid Catalyzed Intermolecular [2σ + 3π] Photocycloadditions.

Authors

Tianlei Du, Yunzhi Xie, Qiujie Qin, Kun Yin, Jian Li, Xinyao Li, Zijun Zhou

Published in

Organic letters. Sep 30, 2025. Epub Sep 30, 2025.

Abstract

Herein, we introduce an innovative approach employing a direct visible-light-excited Lewis acid-catalyzed [2σ + 3π] cycloaddition reaction between bicyclo[1.1.0]butanes and α-vinyl azides via diradical intermediate. This transformation proceeds efficiently in the absence of any external photocatalyst produces versatile 2-azabicyclo[3.1.1]heptene derivatives with a broad substrate scope, achieving yields of up to 94% across 34 examples. The synthetic practicality was further demonstrated through a scaled-up reaction, and the transformation of the imidazole auxiliary into an ester group.

PMID:
41025709
Bibliographic data and abstract were imported from PubMed on 30 Sep 2025.

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