Evaluation of the glymphatic system using the DTI-ALPS index in type 2 diabetes mellitus-induced cognitive impairment.

Authors

Nan Wang, Rendi Yin, Yao Fang, Xiaole Wei, Li Shen, Wei Feng, Haorui Lv, Xiaoyan Zhou, Chao Zhang, Changjiang Ying, Xuan Liu

Published in

Journal of clinical imaging science. Volume 15. Pages 31. Epub Aug 22, 2025.

Abstract

The objective of the study is to assess the utility of the perivascular space diffusion tensor imaging - along the perivascular space (DTI-ALPS) index in evaluating the activity of the brain glymphatic system in patients with type 2 diabetes mellitus (T2DM) and cognitive impairment.
This study included 40 T2DM patients with cognitive impairment and 40 healthy controls (HCs). All participants underwent DTI, and the DTI-ALPS index was calculated based on relevant DTI parameters. Statistical analyses were performed using the Statistical Package for the Social Sciences version 26.0, with significance set at P < 0.05.
The DTI-ALPS index in T2DM patients with cognitive impairment were significantly lower than that of the HCs. A significant negative correlation was observed between the DTI-ALPS index and glycated hemoglobin levels, while positive correlations were found with vitamin D, Montreal Cognitive Assessment scores, and high-density lipoprotein cholesterol levels.
This study confirms glymphatic dysfunction in T2DM patients with cognitive impairment, as indicated by the reduced DTI-ALPS index. Furthermore, it demonstrates the feasibility of utilizing the DTI-ALPS method to assess glymphatic system activity in this patient population.

PMID:
41031311
Bibliographic data and abstract were imported from PubMed on 01 Oct 2025.

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