Authors
Ziyuan Huang, Vishaldeep Kaur Sekhon, Roozbeh Sadeghian, Maria L Vaida, Cynthia Jo, Beth A McCormick, Doyle V Ward, Vanni Bucci, John P Haran
Published in
IEEE access : practical innovations, open solutions. Volume 13. Pages 145953-145967. Epub Aug 18, 2025.
Abstract
Alzheimer's Disease Analysis Model Generation 1 (ADAM-1) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to enhance the understanding and classification of Alzheimer's disease (AD). By leveraging the agentic system with LLM, ADAM-1 produces insights from diverse data sources and contextualizes the findings with literature-driven evidence. A comparative evaluation with XGBoost revealed a significantly improved mean F1 score and significantly reduced variance for ADAM-1, highlighting its robustness and consistency, particularly when utilizing human biological data. Although currently tailored for binary classification tasks with two data modalities, future iterations will aim to incorporate additional data types, such as neuroimaging and peripheral biomarkers, and expand them to predict disease progression, thereby broadening ADAM-1's scalability and applicability in AD research and diagnostic applications.
PMID:
41036149
Bibliographic data and abstract were imported from PubMed on 02 Oct 2025.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 37
- Comments 0