Authors
Dieudonné Makaba Mvumbi, Jean-Marie Kayembe, Hippolyte Situakibanza, Thierry L Bobanga, Célestin N Nsibu, Georges L Mvumbi, Pierrette Melin, Patrick De Mol, Marie-Pierre Hayette
Published in
Malaria journal. Volume 14. Pages 354. Sep 17, 2015. Epub Sep 17, 2015.
Abstract
Malaria cases were estimated to 207 million in 2013. One of the problems of malaria control is the emergence and spread of Plasmodium falciparum strains that become resistant to almost all drugs available. Monitoring drug resistance is essential for early detection and subsequent prevention of the spread of drug resistance by timely changes of treatment policy. This review was performed to gather all data available on P. falciparum molecular resistance in DR Congo, as baseline for future assessments.
The search for this review was undertaken using the electronic databases PubMed and Google Scholar using the terms "malaria", "Congo", "resistance", "molecular", "antimalarial", "efficacy". Articles were classified based on year of collecting, year of publication, sample size and characteristics, molecular markers analysed and polymorphisms detected.
Thirteen articles were included and five genes have been analysed in these studies: pfcrt, pfdhps, pfdhfr, pfmdr1 and K13-propeller. The majority of studies included were not representative of the whole country.
This systematic review demonstrates the lack of molecular resistance studies in DRC. Only 13 studies were identified in almost 15 years. The MOH must implement a national surveillance system for monitoring malaria drug resistance and this surveillance should be conducted frequently and country-representative.
PMID:
26376639
Bibliographic data and abstract were imported from PubMed on 05 Oct 2025.
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