Successful Management of Diabetic Foot Ulcer Complicated by Osteomyelitis Using Platelet-Rich Plasma Therapy: A Case Report.

Authors

Saeed Abouei Mehrizi, Nazila Heidari, Amirhossein Heidari, Yekta Ghane, Mohammad Ali Nilforoushzadeh

Published in

Current stem cell research & therapy. Oct 02, 2025. Epub Oct 02, 2025.

Abstract

Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus, affecting up to 15% of diabetic patients and leading to high rates of hospitalization, morbidity, and lower limb amputation.
This case study details the management of a 67-year-old diabetic male patient with a DFU complicated by osteomyelitis. The patient, with a long history of diabetes and multiple comorbidities, was treated with a comprehensive regimen that included antibiotics, debridement, and platelet-rich plasma (PRP) therapy. PRP was administered weekly for 15 weeks. Clinical, laboratory, and imaging data were employed for the evaluation of the disease improvement. As a result, a marked improvement in wound healing was observed, characterized by reduced wound size, accelerated closure of the wound, and enhanced tissue regeneration. However, the patient developed deep vein thrombosis, which was successfully managed with anticoagulants.
The study highlights PRP's potential in DFU treatment due to its regenerative properties despite the risk of adverse effects. The efficacy of PRP aligns with previous studies, showing improved healing rates and infection control. Future research should focus on large-scale trials to optimize PRP protocols and confirm the safety and efficacy of this therapeutic method in DFU.

PMID:
41047674
Bibliographic data and abstract were imported from PubMed on 06 Oct 2025.

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