Rhodium-Catalyzed C-H Heteroarylation and Alkenylation of N-Phenoxyacetamides Using Iodonium Ylides.

Authors

Wenqian Ding, Wanqi Hu, Weiqi Liu, Xiaowei Wu

Published in

The Journal of organic chemistry. Oct 06, 2025. Epub Oct 06, 2025.

Abstract

Herein, we describe a rhodium-catalyzed monoheteroarylation and alkenylation of N-phenoxyacetamides using iodonium ylides derived from cyclo-1,3-diones. This approach efficiently delivers novel heteroarylated and alkenylated products under mild reaction conditions. The protocol showcases good functional group tolerance and a wide substrate scope. Furthermore, this allows for smooth scale-up synthesis. Additional transformation experiments were conducted to highlight the potential synthetic utility of this methodology.

PMID:
41047955
Bibliographic data and abstract were imported from PubMed on 06 Oct 2025.

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