Propolis enhanced sodium alginate hydrogel enriched with copper doped mesoporous bioactive glass nanoparticles for advanced burn care applications.

Authors

Aqsa Aizaz, Muhammad Haseeb Nawaz, Muhammad Sameet Ismat, Md Abdur Rashid, Muhammad Atiq Ur Rehman

Published in

Biotechnology letters. Volume 47. Issue 5. Pages 121. Oct 09, 2025. Epub Oct 09, 2025.

Abstract

Chronic wounds, with prolonged healing time, remain a formidable challenge due to lack of angiogenesis, antimicrobial effect, and biocompatibility of conventional wound dressings. The current study focuses on developing novel copper-doped mesoporous bioactive glass nanoparticles (Cu-MBGNs) doped with Propolis/ Sodium Alginate (ALG) based hydrogel to promote angiogenesis, tissue regeneration, biocompatibility, and antimicrobial efficacy for advanced wound healing applications. Hydrogel was synthesized using a solution-casting method. It was characterized using material and biological characterization techniques. Scanning electron microscopy (SEM) displayed an interconnected porous network with dispersed Cu-MBGNs facilitating hydrogel swelling/deswelling and degradation behavior (75%). Fourier Transform Infrared Spectroscopy (FTIR) confirmed crosslinking between propolis and ALG via hydrogen bonding. Hydrogel exhibited an antimicrobial effect against Escherichia coli and Staphylococcus gallinarum. Cu⁺² promoted vasculogenesis by modulating vascular endothelial growth factor release and cytocompatibility. These results suggest that Propolis/ALG/Cu-MBGNs hydrogel offers cost-effective and sustainable solution for enhanced wound healing.

PMID:
41065965
Bibliographic data and abstract were imported from PubMed on 09 Oct 2025.

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