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Therapeutic roles of hyaluronan and synthases in cartilage.

Created on 12 Oct 2025

Authors

Gengyun Le-Chan, Sunny S K Chan, Cindy A Thomas-Charles, Yingcui Li, Kevin W-H Lo

Published in

Trends in molecular medicine. Oct 10, 2025. Epub Oct 10, 2025.

Abstract

Hyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the role of HAS in matrix assembly, inflammation and the pathogenesis of osteoarthritis (OA).

PMID:
41076400
Bibliographic data and abstract were imported from PubMed on 12 Oct 2025.

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