Visible-Light Induced Radical Cyclization of N-Allylbenzamide with α-Carbonyl Alkyl Bromide for Direct Construction of Dihydroisoquinolones.

Authors

Ya-Qian Shi, Zhengao Huang, Jia-Xin Ning, Xiu-Juan Li, Chang Xu, Rui-Xue Wang, Hong-Li Huang, Fei Gao

Published in

Chemistry, an Asian journal. Pages e70362. Oct 13, 2025. Epub Oct 13, 2025.

Abstract

A visible-light-induced radical cyclization of N-allylbenzamide has been established as an efficient and versatile approach for synthesizing structurally diverse dihydroisoquinolones. Under the catalysis of fac-Ir(ppy)₃, the N-allylbenzamide substrate intercepts an alkyl radical, triggering an intramolecular cyclization cascade followed by proton extrusion to furnish the dihydroisoquinolinone scaffold. This protocol is distinguished by its high efficiency, operational simplicity, broad substrate scope, and excellent tolerance to a wide range of functional groups.

PMID:
41082635
Bibliographic data and abstract were imported from PubMed on 14 Oct 2025.

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