Design and Synthesis of Structural Analogues of β-Phellandrene to Attract the Yellow Peach Moth (Conogethes punctiferalis).

Authors

Qian Xu, Jun-Xiang Zhou, Jie Liu, Tong-Li Jiang, Zhong Li, Nian-Feng Wan, Wu-Lin Yang

Published in

Journal of agricultural and food chemistry. Oct 16, 2025. Epub Oct 16, 2025.

Abstract

Using plant-released volatiles to attract and control pest moths is a key approach to pest management strategies. β-Phellandrene (β-Phe) has been proven to be attractive to the yellow peach moth (Conogethes punctiferalis). Herein, we designed and synthesized 25 structural analogues of β-Phe and identified four compounds (3a, 3d, 4a, and 4g) with high attraction activity. Among them, the ester-containing compound 4g exhibited the highest attraction rate (76.6%) at a concentration of 10 mg/mL, whose stability and accessibility are both superior to β-Phe. Molecular docking results revealed that the target compounds strongly bound to the general odorant-binding protein 1 (GOBP1) of C. punctiferalis via hydrophobic interactions and π-π stacking. Quantum calculations demonstrated that ester groups optimize the electrostatic potential and introduce hydrogen-bonding sites. These findings elucidate structure-activity relationships and molecular recognition mechanisms of volatile attractants, offering insights for eco-friendly pest management strategies.

PMID:
41100739
Bibliographic data and abstract were imported from PubMed on 17 Oct 2025.

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