Degradable Nanocarriers Capable of Gene Delivery Derived from pH-Responsive Polyester: RROP Copolymerization Between Cyclic Ketene Acetals.

Authors

Yiyi Deng, Jonas Debbeler, Anja Traeger, Jens Gaitzsch

Published in

Macromolecular rapid communications. Pages e00722. Oct 16, 2025. Epub Oct 16, 2025.

Abstract

The ability to combine biodegradability with responsive units by radical ring-opening polymerization (RROP) is the ideal setup for a modern drug delivery system. Since the required polymers were recently unlocked by RROP copolymerization between different cyclic ketene acetals (CKAs), we herein prepared a series of polyester copolymers derived from an amine-bearing CKA 6-(iso-propyl)-2-methylene-1,3,6-dioxazocane (ⁱPr-MAC) and 2-methylene-1,3,6-trioxocane (MTC). Functional nanoparticles with tunable sizes and extremely narrow size distributions could be achieved from these copolymers. Comprehensive studies showed that the resulting nanoparticles exhibited tuneable pH-transition points from 6.3 to 7.1 as the ⁱPr-MAC content increased from 10 to 40 mol%, enabling precise pH-triggered control release at varying pH levels. Furthermore, this work demonstrates the potential of these pH-sensitive polyesters as an alternative to traditional polycations, exploring their biocompatibility and gene delivery capability, which suggests a new application prospect for CKA-derived functional polyesters.

PMID:
41100726
Bibliographic data and abstract were imported from PubMed on 17 Oct 2025.

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