One-Pot Assembly of Dihydrofluoren-3-ones via Intramolecular Annulation of Alkynyl-Alkynones: A Way to Functionalized Fluorenes.

Authors

Chada Raji Reddy, Ankita Kumari, Adla Vijender, Shiva Kumar Kota Balaji, René Grée

Published in

The Journal of organic chemistry. Oct 17, 2025. Epub Oct 17, 2025.

Abstract

Herein, we reveal an approach for the synthesis of a unique structural framework, dihydrofluoren-3-one, from the reaction of propargylic alcohol with alkynyl silyl enol ether. The transformation proceeds through acid-catalyzed propargylation of silyl enol ether leading to alkynyl-alkynones and subsequent intramolecular annulation (3+2 cycloaddition) in the presence of PPh₃AuNTf₂ (2 mol %). This novel dihydrofluoren-3-one motif was found to be a versatile precursor to provide diverse functionalized fluorenes.

PMID:
41108037
Bibliographic data and abstract were imported from PubMed on 18 Oct 2025.

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