Prognostic Impact of Mitral Valve Sphericity Index After Mitral Valve Transcatheter Edge-to-Edge Repair in Functional Mitral Regurgitation.

Authors

Takanori Kawamoto, Chihiro Koyanagi, Yuichiro Minami, Yukako Tanaka, Masafumi Yoshikawa, Eiji Shibahashi, Kaoru Haruki, Risako Nakao, Yusuke Inagaki, Hisao Otsuki, Tomohito Kogure, Satoru Domoto, Kyomi Ashihara, Hiroshi Niinami, Junichi Yamaguchi

Published in

Circulation journal : official journal of the Japanese Circulation Society. Oct 18, 2025. Epub Oct 18, 2025.

Abstract

Changes in mitral valve (MV) morphology during MV transcatheter edge-to-edge repair (MV-TEER) are associated with short-term reduction of mitral regurgitation (MR). However, whether these changes are associated with prognosis remains unclear. Using 3-dimensional transesophageal echocardiography, this study evaluated the impact of MV morphological parameters on the mid-term prognosis of patients with functional MR (FMR).
We analyzed 99 patients with FMR who were treated with MV-TEER. The primary endpoint was a composite of all-cause mortality and hospitalization due to heart failure. Patients were divided into 2 groups based on the post-procedural sphericity index of the mitral valve (SI-MV), which is the ratio of the vertical to horizontal MV diameter. Using receiver operating characteristic curve (ROC) analysis for the primary endpoint, the SI-MV cut-off value was determined to be 0.86. The incidence of the primary endpoint was significantly (log-rank P=0.013) higher among patients with a post-procedural SI-MV >0.86 (circular MV morphology) than among those with post-procedural SI-MV ≤0.86 (elliptical MV morphology). Post-procedural SI-MV >0.86 was an independent determinant of the primary endpoint in multivariate analysis (hazard ratio 2.35; 95% confidence interval 1.25-4.42; P=0.0077).
A larger post-procedural SI-MV is associated with increased mid-term adverse clinical events after MV-TEER in patients with FMR.

PMID:
41110948
Bibliographic data and abstract were imported from PubMed on 20 Oct 2025.

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