Comparative in vivo PET imaging of silica microparticles: shape-dependent blood circulation and short-term biodistribution.

Authors

Jan Grzelak, Martí Gich, Rafael T M de Rosales, Anna Roig, Juan Pellico

Published in

Dalton transactions (Cambridge, England : 2003). Oct 20, 2025. Epub Oct 20, 2025.

Abstract

Particles at the nanometric-micrometric interface hold promise by combining the drug-loading capacity of microparticles with the systemic benefits of nanoparticles. We assess the in vivo behaviour in mice via PET imaging of silica rods and spheres (∼1 μm), showing different biodistributions thus highlighting the potential for shape-dependent targeting.

PMID:
41111328
Bibliographic data and abstract were imported from PubMed on 20 Oct 2025.

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