Quantification and material modelling of the localized non-bone regions in the trabecular architecture of the sacrum.

Authors

Immanuel Ries, Anantha Narayanan Ramakrishnan, Amadeus Alcântara, Munir Skaf, Christopher Ludtka, Thomas Mendel, Friederike Klauke, Stefan Schwan

Published in

Computer methods in biomechanics and biomedical engineering. Pages 1-16. Oct 22, 2025. Epub Oct 22, 2025.

Abstract

Simulating fractures using CT-based bone models enables personalized treatment. However, most commercially-available applications only use bone mineral density (BMD) to calculate Young's modulus, solely considering the mineralized phase. Our methodology maps sacral region material properties by: (1) segmenting bone into mineralized / non-mineralized volumes, (2) calculating mineralized region Young's modulus via BMD approach and non-mineralized region modulus via volume fraction, and (3) generating a FE mesh with material mapping. This enables stress field analysis and Young's modulus approximation for low Hounsfield values. Considering the internal composition of bone is crucial for improving patient-specific FE models and assessing pelvic fractures.

PMID:
41124577
Bibliographic data and abstract were imported from PubMed on 23 Oct 2025.

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