Microbial Metabolites: An Underexploited Arsenal to Combat Antibiotic Resistance Dissemination.

Authors

Xinyi Li, Litao Wei, Ling Li, Haining Huang, Yinguang Chen

Published in

Environment & health (Washington, D.C.). Volume 3. Issue 10. Pages 1121-1124. Oct 17, 2025. Epub Jul 01, 2025.

Abstract

The relentless global proliferation of antibiotic resistance genes (ARGs) poses a profound threat to public health and ecological stability. Unlike static chemical pollutants, ARGs propagate through horizontal gene transfer (HGT)a dynamic biological process that facilitates the cross-taxa dissemination of resistance determinants among environmental, commensal, and pathogenic microbes. This ecological amplification of resistance undermines both clinical therapies and environmental resilience, rendering the understanding and control of ARG dissemination a critical challenge in the fight against antibiotic resistance.

PMID:
41127838
Bibliographic data and abstract were imported from PubMed on 23 Oct 2025.

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