Elevated hemoglobin A1c confounds thalassemia diagnosis by lowering HbA2 levels.

Authors

Jeroen Slaats, Erfan Nur, Harriët Heijboer, Eva Rettenbacher, Rob van Zwieten, Esther Miltenburg, Joyce Reijerse, Nienke Verhaart, Wouter van den Eshof, Bart Biemond, Henrike Hamer

Published in

Annals of clinical biochemistry. Pages 45632251395562. Oct 27, 2025. Epub Oct 27, 2025.

Abstract

Thalassemias are inherited disorders caused by reduced production of structurally normal hemoglobin chains. Hemoglobin A2 (HbA2) constitutes an important parameter in the diagnostic evaluation of thalassemias. Insight into the factors that modulate HbA2 levels is critical for correct interpretation of laboratory results in cases where thalassemia is suspected. This study reveals that elevated HbA1c levels due to chronic hyperglycemia represent a novel confounding factor in the diagnostic evaluation of thalassemias, as it results in decreased HbA2 levels.

PMID:
41145236
Bibliographic data and abstract were imported from PubMed on 28 Oct 2025.

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