Diagnostic and Predictive Utility of Plasma Phosphoethanolamine Levels in Depressive Disorder: A Naturalistic Observational Study.

Authors

Noriyuki Kawamura, Akinori Nakata, Tsuyoto Harada, Yoshiaki Ohashi, Hajime Sato, Kazunori Sasaki, Shoichiro Tsugane

Published in

International journal of methods in psychiatric research. Volume 34. Issue 4. Pages e70041.

Abstract

Plasma phosphoethanolamine (PEA) has been proposed as a potential biomarker for depressive disorder. To further assess its diagnostic utility and relevance across psychiatric conditions, we conducted a larger observational study in a psychiatric primary care setting.
Between 2013 and 2020, 576 patients underwent DSM-5-based psychiatric assessments. Plasma PEA levels were measured in 295 patients with depressive disorders, 264 with other psychiatric disorders, and 17 with physical illnesses.
PEA demonstrated moderate or high diagnostic accuracy for depressive disorder (AUC = 0.81, 95% CI: 0.78-0.85). Lower PEA levels were significantly associated with depression (OR = 16.30, p < 0.001).
These findings suggest that plasma PEA concentration may serve as a useful biomarker for depressive disorder. Further studies are warranted to explore its potential relationship with white matter pathology in psychiatric conditions.

PMID:
41147126
Bibliographic data and abstract were imported from PubMed on 28 Oct 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.