Integrated network analysis platform for protein-protein interactions.

Authors

Jianmin Wu, Tea Vallenius, Kristian Ovaska, Jukka Westermarck, Tomi P Mäkelä, Sampsa Hautaniemi

Published in

Nature methods. Volume 6. Issue 1. Pages 75-7. Epub Dec 14, 2008.

Abstract

There is an increasing demand for network analysis of protein-protein interactions (PPIs). We introduce a web-based protein interaction network analysis platform (PINA), which integrates PPI data from six databases and provides network construction, filtering, analysis and visualization tools. We demonstrated the advantages of PINA by analyzing two human PPI networks; our results suggested a link between LKB1 and TGFbeta signaling, and revealed possible competitive interactors of p53 and c-Jun.

PMID:
19079255
Bibliographic data and abstract were imported from PubMed on 06 Nov 2025.

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