A Mesh-Duox pathway regulates homeostasis in the insect gut.

Authors

Xiaoping Xiao, Lijuan Yang, Xiaojing Pang, Rudian Zhang, Yibin Zhu, Penghua Wang, Guanjun Gao, Gong Cheng

Published in

Nature microbiology. Volume 2. Pages 17020. Mar 01, 2017. Epub Mar 01, 2017.

Abstract

The metazoan gut harbours complex communities of commensal and symbiotic bacterial microorganisms. The quantity and quality of these microorganisms fluctuate dynamically in response to physiological changes. The mechanisms that hosts have developed to respond to and manage such dynamic changes and maintain homeostasis remain largely unknown. Here, we identify a dual oxidase (Duox)-regulating pathway that contributes to maintaining homeostasis in the gut of both Aedes aegypti and Drosophila melanogaster. We show that a gut-membrane-associated protein, named Mesh, plays an important role in controlling the proliferation of gut bacteria by regulating Duox expression through an Arrestin-mediated MAPK JNK/ERK phosphorylation cascade. Expression of both Mesh and Duox is correlated with the gut bacterial microbiome, which, in mosquitoes, increases dramatically soon after a blood meal. Ablation of Mesh abolishes Duox induction, leading to an increase of the gut microbiome load. Our study reveals that the Mesh-mediated signalling pathway is a central homeostatic mechanism of the insect gut.

PMID:
28248301
Bibliographic data and abstract were imported from PubMed on 07 Nov 2025.

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