Performance and Its Limits in Rigid Body Protein-Protein Docking.

Authors

Israel T Desta, Kathryn A Porter, Bing Xia, Dima Kozakov, Sandor Vajda

Published in

Structure (London, England : 1993). Volume 28. Issue 9. Pages 1071-1081.e3. Sep 01, 2020. Epub Jul 09, 2020.

Abstract

The development of fast Fourier transform (FFT) algorithms enabled the sampling of billions of complex conformations and thus revolutionized protein-protein docking. FFT-based methods are now widely available and have been used in hundreds of thousands of docking calculations. Although the methods perform "soft" docking, which allows for some overlap of component proteins, the rigid body assumption clearly introduces limitations on accuracy and reliability. In addition, the method can work only with energy expressions represented by sums of correlation functions. In this paper we use a well-established protein-protein docking benchmark set to evaluate the results of these limitations by focusing on the performance of the docking server ClusPro, which implements one of the best rigid body methods. Furthermore, we explore the theoretical limits of accuracy when using established energy terms for scoring, provide comparison with flexible docking algorithms, and review the historical performance of servers in the CAPRI docking experiment.

PMID:
32649857
Bibliographic data and abstract were imported from PubMed on 11 Nov 2025.

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