AI-aided diagnostic performance for prostate MRI: systematic review and meta-analysis.

Authors

Xin-Ru Xie, Ying Hou, Shuai Shan, Rui Zhi, Chen-Jiang Wu, Yi-Fan Xia, Wei Xi, Zhen Li, Yu-Dong Zhang

Published in

Prostate cancer and prostatic diseases. Nov 21, 2025. Epub Nov 21, 2025.

Abstract

AI is increasingly integrated within prostate cancer diagnosis pathway.
To provide estimates of diagnostic accuracy of AI assistance for clinically significant prostate cancer (csPCa) via MRI.
A systematic search of PubMed, Embase, Cochrane, Scopus and Web of Science from January 2017 to October 2024 was performed for studies on the diagnostic utility of AI for prostate MRI. Diagnostic performance metrics were synthesized through hierarchical summary receiver operating characteristic modeling with random-effects assumptions. Specially, to test inferiority and potential superiority of AI, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), cancer detection rate (CDR), and accuracy was pairwisely compared between AI and radiologists in study level using odds ratios (ORs) with Z-statistics.
7398 patients from 29 studies with AI-vs-human pairwise comparison were included. When acting as an assistant to human readers, AI demonstrated superior performance compared to stand-alone human readers in diagnosing csPCa via MRI, specifically with higher sensitivity (86.5% vs 82.6%, P = 0.001), specificity (57.8% vs 50.0%, P = 0.028), PPV (64.3% vs 58.9%, P = 0.001), and NPV (82.9% vs 76.5%, P = 0.001) while maintaining comparable CDR (40.5% vs 38.6%, P = 0.093). When used as standalone readers, AI exhibited higher specificity (58.7% vs 48.7%, P = 0.026) but at the cost of reduced sensitivity (87.2% vs 90.1%, P = 0.017). Subgroup analysis indicated that readers of varying experience levels could all improve their diagnostic performance with AI assistance.
Integrating AI as an assistant in csPCa diagnostic workflows could enhance accuracy, particularly for less experienced readers.
Trial Name: The efficiency comparison of radiologists with or without assistance of artificial intelligence in prostate cancer diagnosis: a meta-analysis. Registration date: April 17, 2024.
CRD42024533016. Registration information available at: https://www.crd.york.ac.uk/PROSPERO/ .

PMID:
41272268
Bibliographic data and abstract were imported from PubMed on 22 Nov 2025.

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