Hydroxylated iodinated boron clusters: a tunable platform for enhanced membrane transport and biocompatibility.

Authors

Satoshi Yamamoto, Rikuto Nakajima, Yuya Hirai, Yumiko K Kawamura, Yoshimasa Makita, Taro Kitazawa, Mutsumi Kimura, Yu Kitazawa

Published in

Chemical communications (Cambridge, England). Dec 10, 2025. Epub Dec 10, 2025.

Abstract

[B₁₂I₁₂]^2- exhibits potent membrane transport yet high cytotoxicity. Stepwise hydroxylation moderates chaotropicity, balancing permeability and biocompatibility. Notably, mono-hydroxylation retains transport activity while minimizing toxicity, whereas further hydroxylation ablates permeability. This strategy advances safe, efficient boron cluster-based carriers for drug delivery and related biomedical applications.

PMID:
41368691
Bibliographic data and abstract were imported from PubMed on 10 Dec 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.