Reduced risk of dementia with recombinant zoster vaccine in US adults age 65 or older.

Authors

Susan Dos Reis, Phuong Tran, Kareshma Mohanty, Alejandro Amill-Rosario, Abree Johnson, Kathleen Ryan, Hannah Alsdurf, Driss Oraichi, Huifeng Yun

Published in

Alzheimer's & dementia : the journal of the Alzheimer's Association. Volume 22. Issue 5. Pages e71407.

Abstract

Herpes zoster vaccines may lower the risk of dementia onset. We evaluated new-onset dementia among US Medicare beneficiaries ≥65 years old following recombinant zoster vaccination (RZV).
We matched one RZV-exposed to two RZV-unvaccinated on age, sex, and race/ethnicity. Individuals were ≥65 years old on the RZV dose 2 date (RZV-exposed) or preventive care visit date (RZV-unvaccinated), enrolled in Medicare ≥11 months before this date, and had no pre-existing dementia of any type. Weighted Cox proportional hazards models generated hazard ratios (HR) of new-onset dementia, Alzheimer's disease (AD), and vascular dementia (VD).
The incidence per 1000 person-years of new-onset dementia for 15,061/502,845 RZV-exposed and 36,526/1,005,690 RZV-unvaccinated was 10.45 and 15.73, respectively. Time-dependent HRs (95% confidence interval) for ≤3 and >3 years' follow-up were as follows: 0.67 (0.65, 0.68); 0.74 (0.69, 0.79) for dementia; 0.72 (0.69, 0.74); 0.83 (0.74, 0.94) for AD; 0.67 (0.64, 0.70); 0.66 (0.57, 0.78) for VD.
Two-dose RZV may lower new-onset dementia, AD, and VD risk.

PMID:
42050365
Bibliographic data and abstract were imported from PubMed on 29 Apr 2026.

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