Authors
Ruoshi Wang, Yuqing Wang, Yanfei Mo, Heng Zhang, Gaoxiang Ma
Published in
Frontiers in pharmacology. Volume 17. Pages 1731723. Epub Apr 15, 2026.
Abstract
Gynostemma pentaphyllum (Thunb.) Makino is a traditional "medicine food homology" plant widely consumed in Asia to promote health. Its safety profile makes it a promising diabetes candidate. This study systematically evaluates its efficacy in glycemic control and elucidates its mechanisms of action.
We conducted a meta-analysis of clinical studies from PubMed, CNKI, and Embase. Random-effects models calculated pooled mean differences (MD) for fasting plasma glucose (FPG), 2-h postprandial glucose (2hPG), and glycated hemoglobin (HbA1c). A systematic review also summarized its antidiabetic mechanisms.
Eight studies involving 584 patients were included. Gynostemma pentaphyllum significantly reduced FPG (MD = -0.79 mmol/L, 95% CI = -1.08 to -0.51), HbA1c (MD = -1.01%, 95% CI = -1.41 to -0.61), and 2hPG (MD = -0.90 mmol/L, 95% CI = -1.95 to -0.15). Long-term and monotherapy treatments showed superior efficacy. The mechanistic review revealed hypoglycemic effects via multiple pathways, including enhanced glucose uptake, reduced glucose production, increased insulin secretion, and improved insulin resistance.
Combined clinical and mechanistic findings demonstrate that Gynostemma pentaphyllum provides effective glycemic control through multi-target pharmacological mechanisms, solidifying its potential as a comprehensive therapeutic approach for diabetes management.
PMID:
42064816
Bibliographic data and abstract were imported from PubMed on 01 May 2026.
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