Authors
Weizhuang Gong, Zixuan Yue, Zhongbao Luo, Cheng Wang, Zhixian Zhu, Zhonghua Ni, Nan Xiang
Published in
ACS sensors. Jun 01, 2026. Epub Jun 01, 2026.
Abstract
As the largest external barrier of the human body, the skin is essential to overall health and quality of life. Conventional skin health management faces limitations such as insufficient real-time monitoring and lack of personalization. Flexible wearable devices have recently emerged as a transformative technology, enabling non-invasive sensing and targeted therapy with high skin compatibility. This review comprehensively summarizes recent advances in flexible wearable closed-loop diagnostic and therapeutic systems for skin health management. It outlines the core technological components, including skin bioinformation collection, biosignal monitoring, signal transmission and data analysis, and targeted intervention. Key applications in physiological and pathological monitoring, wound healing, drug delivery, and physical therapy are discussed. Furthermore, the innovation trajectory of closed-loop systems is clarified, key challenges are analyzed, and targeted solutions are proposed. Future directions are prospected from cross-disciplinary views including digital twins and personalized medicine, establishing a new paradigm for real-time, personalized, and continuous skin health management.
PMID:
42224058
Bibliographic data and abstract were imported from PubMed on 02 Jun 2026.
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