Authors
Bufu Tang, Yaling Lin, Songhua Cai, Jingqin Ma, Wei Zhang, Tong Jiang, Ruiqing Gao, Yongjie Zhou, Xuran Jin, Yuyu Guan, Wen Zhang, Lingxiao Liu, Zhiping Yan, Peng Luo, Xudong Qu
Published in
Molecular cancer. Volume 25. Issue 1. Apr 09, 2026. Epub Apr 09, 2026.
Abstract
Ferroptosis is a novel form of programmed cell death defined by iron-dependent, reactive oxygen species (ROS)-mediated peroxidation of membrane phospholipids containing polyunsaturated fatty acyl chains. Since 2020, research interest in ferroptosis has surged exponentially, outpacing that of other cell death modalities and establishing it as a pivotal regulatory target in oncology. This review offers three key novel contributions compared to prior summaries: first, it systematically integrates the context-dependent roles of ferroptosis either synergistic sensitization or resistance in cancer multi-disciplinary treatment (MDT), including chemotherapy, targeted therapy, radiotherapy, interventional therapy and immunotherapy, with a focus on clinical trial evidence from the past five years; second, it deciphers the dynamic crosstalk between ferroptosis and core components of the tumor immune microenvironment (TIME), while clarifying the regulatory impacts of microenvironmental factors (pH, hypoxia, gut microbiota); third, it comprehensively summarizes breakthrough advances in nanoplatform based ferroptosis regulation, structured around two complementary perspectives: endogenous TME-responsive systems and exogenous stimulus triggered systems. This review aims to bridge basic mechanisms with clinical applicability, providing a framework for translating ferroptosis targeted strategies into optimized MDT regimens.
The online version contains supplementary material available at 10.1186/s12943-026-02590-0.
PMID:
41957797
Bibliographic data and abstract were imported from PubMed on 14 Jun 2026.
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