A case Report of Pulmonary Langerhans Cell Histiocytosis in a Child.

Authors

Ziyin Huang, Zuoxin Deng, Fang Lan, Lifang Nong, Chunyun Fu

Published in

Clinical laboratory. Volume 72. Issue 6. Jun 01, 2026.

Abstract

Langerhans cell histiocytosis (LCH) is a clonal neoplastic disorder characterized by the aberrant proliferation of CD1a+/CD207+dendritic cells that infiltrate tissues and organs, resulting in organ dysfunction.
This case report describes a 2-year-old boy who presented with abdominal pain and fever. The etiology was ultimately confirmed through clinical symptoms, imaging studies, pulmonary histopathological examination, and genetic testing.
The final diagnosis was pediatric pulmonary Langerhans cell histiocytosis (PLCH).
Although pulmonary involvement is not classified as a high-risk in consensus guidelines, PLCH requires diagnostic consideration in children presenting with persistent respiratory symptoms and recurrent fever.

PMID:
42295309
Bibliographic data and abstract were imported from PubMed on 15 Jun 2026.

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