Authors
Qiangfei Wang, Tian Jiang, Qingchao Mao, Sicong Jiang, Aifang Li, Qunchao Zhu
Published in
Journal of visualized experiments : JoVE. Issue 231. May 29, 2026. Epub May 29, 2026.
Abstract
This study presents a structured, reproducible retrospective workflow for evaluating combination pharmacological therapy in patients with non-variceal upper gastrointestinal bleeding (NVUGIB) using electronic medical record (EMR) data. The goal of this protocol is to provide a standardized framework for extracting, processing, and analyzing retrospective clinical data to assess treatment outcomes. The workflow includes database querying, application of inclusion and exclusion criteria, group allocation based on treatment records, and systematic extraction of predefined clinical and laboratory outcomes. Data are analyzed using a stepwise statistical approach to generate representative outcomes. Representative results demonstrate that combination therapy with somatostatin and omeprazole is associated with improved haemostatic outcomes, reduced rebleeding rates, and enhanced clinical recovery compared with omeprazole alone, without an increase in adverse events. These findings are hypothesis-generating and should be interpreted as association-based observations. This protocol emphasizes reproducibility and can be applied across institutions to evaluate pharmacological interventions using retrospective clinical datasets. The method provides a practical framework for clinicians and researchers to assess treatment effectiveness in real-world settings and may be adapted to other therapeutic areas requiring retrospective outcome evaluation.
PMID:
42296138
Bibliographic data and abstract were imported from PubMed on 16 Jun 2026.
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