Authors
Shuo Qiao, Wenjing Yu, Hong Kou, Xiaoman Wu, Beibei Li, Xiao Yang
Published in
Journal of visualized experiments : JoVE. Issue 231. May 29, 2026. Epub May 29, 2026.
Abstract
Postoperative adjuvant radiotherapy for breast cancer is frequently associated with acute treatment-related symptoms that negatively affect quality of life (QoL). This prospective controlled study evaluated the efficacy of an electronic patient-reported outcome (ePRO)-guided symptom management pathway integrated into routine radiotherapy care. A total of 117 patients were enrolled, and 105 completed radiotherapy and were included in the final analysis (usual care, n = 52; usual care plus ePRO-guided management, n = 53). The primary endpoint was the longitudinal trajectory of acute symptom burden, while the secondary endpoint was change in QoL during treatment. Validated symptom and QoL instruments were administered longitudinally, and outcomes were analyzed using linear mixed-effects models adjusted for prespecified baseline covariates. Compared with usual care, the ePRO-guided group demonstrated significantly lower peak symptom severity, faster symptom recovery toward the end of treatment, and more favorable longitudinal trends in global and breast cancer-specific QoL domains (all P < 0.05). The ePRO-guided pathway integrated weekly monitoring, automated alert generation, and nurse-led stratified interventions into a closed-loop management workflow. These findings suggest that integrating ePRO-triggered symptom management into routine radiotherapy practice may reduce acute symptom burden and support patient-centered care during breast cancer radiotherapy.
PMID:
42296021
Bibliographic data and abstract were imported from PubMed on 16 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 4
- Comments 0