Authors
Di Zhang, Lingyun Guo, Haoping Xin, Lihui Ren, Siyun Song, Yunfei Bai, Chengwu Zhang, Wen Liu, Lihong Li, Haojiang Wang, Bin Wang, Lixia Guo, Sufang Ma, Boye Zhang, Guodong Ren, Jianfei Liu, Jiangfeng Du, Huimin Liu, Xiaoyuan Ji, Lili Yan
Published in
ACS nano. Jun 15, 2026. Epub Jun 15, 2026.
Abstract
Infected foot wounds often exhibit markedly prolonged healing due to local ischemia, multidrug-resistant pathogens, and chronic inflammation, representing a major clinical challenge. This work reports a piezoelectric heterojunction-based smart textile dressing, in which the heterostructure was constructed via atomic layer deposition (ALD) to achieve precise band-structure engineering. By tailoring the number of ZnO deposition cycles on BaTiO3, the optimized BaTiO3-10ZnO heterojunction (10 ALD cycles) exhibits the most favorable band alignment and a 2.95-fold boost in ROS generation efficiency compared with pristine BaTiO3. The composite is covalently immobilized onto textile fibers via amine-aldehyde condensation, yielding an intelligent textile platform. In a rat plantar infection model, the dressing, activated by walking-triggered mechanical pressure, achieves the most prominent therapeutic outcome, outperforming other ALD-cycle variants and commercial Ag+ dressings. Systematic histological and transcriptomic analyses further unveil its multipronged antibacterial mechanisms, including bacterial membrane disruption, metabolic interference, and oxidative-stress induction. This work offers an innovative strategy for self-powered antimicrobial systems and demonstrates great potential for chronic wound management.
PMID:
42296249
Bibliographic data and abstract were imported from PubMed on 16 Jun 2026.
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