Authors
Manur Gururajachar Janaki, Thirukurungudi Narayanan Vijayasree, Sagarika Nithyanand, Ponnachiparambil Chandrabose Nikhila, Deepak Angamuthu, Kulangarath Chandran Jyothish
Published in
Indian journal of cancer. Volume 63. Issue 1. Pages 18-27. Jan 01, 2026. Epub Jun 09, 2026.
Abstract
Oral cavity cancer (OCC) patients are treated with surgery as the primary modality of treatment world over. This study is aimed to compare surgery with adjuvant radiation practiced at center A with Radical radiation practiced at center B in terms of disease control and quality of life (QOL) for OCC patients.
Wide excision and neck dissection with or without reconstruction was followed by adjuvant radiation with or without chemotherapy in selected cases in center A. Radical chemoradiation was used in center B. Their disease status at 2 years of follow-up was assessed along with QOL. The results were compared between the two centers.
A total of 43 patients from center A and 33 patients from center B were looked at and the 2-year survival rate was 66% and 48%, respectively ( P = 0.04). Among QOL scores, pain in the mouth and shoulder was significantly higher in center A, while scores of social contact and weight losses were significantly higher in center B. Lost to follow-up was higher in center B, 52% versus 12%.
Surgery followed by radiation with or without chemotherapy should be considered for operable OCC and provides better tumor control with a lesser QOL of subscales related to surgery. Wherever surgical expertise is not available, radical chemoradiation is preferred for a better QOL compared to palliative treatment.
PMID:
42301655
Bibliographic data and abstract were imported from PubMed on 16 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 6
- Comments 0