Effect of dezocine on the median effective dose of sufentanil for blunting hemodynamic responses to endotracheal intubation during anesthesia induction.

Authors

Weiwei Ye, Jiansong Yu, Wei Chen, Xiaodan Wang, Donghang Cao, Nanjin Chen

Published in

Journal of thoracic disease. Volume 18. Issue 5. Pages 525. May 31, 2026. Epub May 20, 2026.

Abstract

In clinical practice, dezocine has been used to inhibit sufentanil-induced cough (SIC). The aim of the study was to evaluate the effect of dezocine on the required dose of sufentanil for blunting hemodynamic responses during anesthesia induction and endotracheal intubation in male and female patients.
Adult patients of both sexes with American Society of Anesthesiologists physical status I-II (ASA I-II) undergoing general anesthesia and endotracheal intubation were enrolled. Peri-intubation hemodynamic variables including blood pressure and heart rate were recorded. The Dixon up‑and‑down method was used to calculate the median effective dose (ED50) of sufentanil for attenuating intubation-related hemodynamic reactions. A dose-response curve was generated by the probit analysis in each group.
In females, the ED50 of sufentanil for suppressing intubation responses was 0.23±0.03 µg/kg in the control group and 0.26±0.05 µg/kg in the dezocine group, with no significant between-group difference (P>0.05). In males, the corresponding ED50 values were 0.35±0.03 and 0.43±0.04 µg/kg, respectively (P<0.05). Probit analysis showed that in females, the ED50 [95% confidence interval (CI)] was 0.219 (0.183-0.248) µg/kg in the control group and 0.241 (0.192-0.282) µg/kg in the dezocine group. In males, the ED50 (95% CI) was 0.339 (0.291-0.374) µg/kg and 0.409 (0.357-0.472) µg/kg, respectively. Probit analysis showed that in females, the ED50 (95% CI) was 0.219 (0.183-0.248) µg/kg in the control group and 0.241 (0.192-0.282) µg/kg in the dezocine group. In males, the ED50 (95% CI) was 0.339 (0.291-0.374) µg/kg and 0.409 (0.357-0.472) µg/kg, respectively.
Dezocine increases the sufentanil dose requirement for blunting intubation-related hemodynamic responses in male patients, while no obvious influence is observed in female patients.

PMID:
42306709
Bibliographic data and abstract were imported from PubMed on 17 Jun 2026.

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