Eremophilane Sesquiterpenes With Antichlamydial Activity Isolated From Ligularia macrophylla.

Authors

Na Gao, Guo-Li Li, Xiang-Tao Zha, Hong-Ying Yang, Yi-Lin He, Tong Shen

Published in

Chemistry & biodiversity. Volume 23. Issue 6. Pages e71429.

Abstract

Three new eremophilane-type sesquiterpenoids (1-3), along with two known eremophilenolides (4-5), were obtained from the whole of Ligularia macrophylla. The structures were determined by spectroscopic analysis and comparison with reported data. Compounds 1-5 were evaluated for their antichlamydial activities by an experimental model employing L929 cells infected with Chlamydia abortus. Compound 3, at a concentration of 100 µM, exhibited activity comparable to that of the positive control tetracycline at a concentration of 20 µg/mL, while showing no cytotoxicity. Preliminary structure-activity relationships for these eremophilenolides are reported.

PMID:
42307847
Bibliographic data and abstract were imported from PubMed on 17 Jun 2026.

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