Authors
Haixu Wu, Duoyuan Chen, Jun Li, Tao Zhou, Zhenkun Zhuang, Zhiwei Niu, Zeyu Du, Yongjie Chen, Shunqin Chuan, Chunyan Xu, Xun Liao, Xiaoyu Meng, Jiali Lu, Wenxue Cui, Youning Lin, Fubaoqian Huang, Kuo Liao, Yan Liu, Tao Yang, Jing Chen, Hui Wang, Zhiqiang Dong, Longqi Liu, Xiaodong Fang, Xun Xu, Qingwei Li, Yue Pang, Shiping Liu, Bing Su
Published in
Science (New York, N.Y.). Volume 392. Issue 6804. Pages eaea2535. Jun 18, 2026. Epub Jun 18, 2026.
Abstract
The lamprey occupies a pivotal position for elucidating vertebrate brain evolution. Using spatial transcriptomics and single-nucleus RNA sequencing, we generated a three-dimensional molecular atlas of the lamprey brain, identifying 209 distinct cell clusters across 14 regions. Cross-species comparisons revealed broad conservation of regional spatial architecture, defining an ancestral organizational blueprint. Within this conserved framework, however, marked lineage-specific divergence emerged. We observed extensive neuronal specialization across vertebrate lineages, accompanied by regulatory shifts associated with spatial reorganization and functional diversification of neuronal populations. Additionally, our results suggest that a cerebellum-like architecture predates the jawed vertebrate cerebellum. Together, these findings identified constraints on neural organization and detected cellular innovations driving evolutionary diversification.
PMID:
42313957
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.
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