Feasibility Study of Balloon Angioplasty for the Treatment of Ophthalmic Artery Stenoses in Patients With Geographic Atrophy.

Authors

Mario J Saravia, Jimena Rojas, Christan de Los Santos, Pablo Bazterrechea, Fernanda Forgues, Nicolas Monteros, Juan Manuel Cortalezzi, Ignacio Zeolite, Enrique Sgattoni, Luis Zeman, Matko Vidosevich, Guillermo Magnano, Marcelo Zas, Ezequiel Rosendi, Jeff Franco, Michael W Calhoun, Luana R Wilbur, Philip J Rosenfeld, Pedro Lylyk

Published in

Ophthalmic surgery, lasers & imaging retina. Pages 1-9. Jun 16, 2026. Epub Jun 16, 2026.

Abstract

A safety and feasibility study was conducted using balloon angioplasty to treat ophthalmic artery (OA) stenoses in patients with age-related macular degeneration (AMD) with geographic atrophy (GA).
Patients ≥ 60 years of age received OA angioplasty using an investigational catheter system and were followed for 6 months. Changes in stenosis, best-corrected visual acuity (BCVA), MNRead acuity charts, ophthalmic imaging, and a validated questionnaire were evaluated.
Eleven patients were treated. All adverse events were treated as needed and resolved without sequelae. Treated patients demonstrated a mean improvement over baseline in BCVA (P = .01) and reading speed (P = .03) at study exit. Mean subfoveal choroidal thickness increased over baseline (P = .004) and fellow eyes (P = .03) through week 4, remaining above baseline at study exit. Participants reported mean improvements in both mobility and reading.
Treating OA stenoses using angioplasty in patients with GA was safe with apparent visual function benefit.

PMID:
42314011
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.

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