Dietary fiber intake and gallstones: The mediating role of serum lipids.

Authors

Wenli Jiang, Furui Wang, Yuyu Lin, Xiu Luo, Ya Zheng, Jun Yan, Wei Yang, Zenan Hu

Published in

The Journal of international medical research. Volume 54. Issue 6. Pages 3000605261451085. Epub Jun 18, 2026.

Abstract

ObjectiveTo investigate the mediating role of serum lipids in the association between dietary fiber intake and gallstones prevalence.MethodsThis study analyzed the data from 4896 adults participating in the National Health and Nutrition Examination Survey conducted between 2017-March 2020 and August 2021-August 2023. Logistic regression models and subgroup analyses were conducted to assess the correlation between dietary fiber intake and gallstone prevalence. Additionally, smooth curve fitting based on the generalized additive model was applied to elucidate nonlinear relationships. The mediating effects of lipid-related indicators, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, total cholesterol, non-high-density lipoprotein cholesterol, residual cholesterol, and atherogenic index of plasma were also evaluated.ResultsHigh-density lipoprotein cholesterol and atherogenic index of plasma significantly mediated the association between dietary fiber intake and gallstone prevalence, with mediation proportions of 5.06% and 4.26%, respectively (all p < 0.05). Conversely, the mediating effects of other lipid parameters (non-high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total cholesterol, triglycerides, and residual cholesterol) were not statistically significant.ConclusionThere exists a complex relationship between dietary fiber intake, serum lipid levels, and gallstone formation, with serum lipids potentially serving as mediators. Future research should explore this mechanism in greater depth to offer new insights for the prevention and treatment of gallstones.

PMID:
42315329
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.