Authors
Christian Messina
Published in
European journal of internal medicine. Pages 107031. Jun 18, 2026. Epub Jun 18, 2026.
Abstract
Severe acquired brain injury (sABI) requires coordinated management across the acute and post-acute phases to optimize recovery and long-term outcomes. We read with great interest the recent study by Grifoni and colleagues, which demonstrated the benefits of an interdisciplinary co-management model between the Neuro-Intensive Care Unit and the Intensive Neurorehabilitation Unit, resulting in reduced length of stay, fewer emergency transfers, lower mortality, and improved rehabilitation allocation. Building upon these findings, we highlight the potential importance of systematically considering Critical Illness Polyneuropathy and Myopathy (CIPNM), a common but frequently underrecognized complication of critical illness. CIPNM is a major cause of intensive care unit-acquired weakness and has been associated with prolonged mechanical ventilation, impaired functional recovery, increased morbidity, and higher mortality. Previous studies have reported a high prevalence of CIPNM among patients with sABI, particularly in those with disorders of consciousness admitted to rehabilitation settings. Because no specific pharmacological treatment is currently available, early recognition remains crucial to guide patient management, optimize rehabilitation strategies, and improve functional outcomes. Greater awareness of CIPNM within integrated neurocritical and neurorehabilitation pathways may contribute to more accurate prognostic assessment and ultimately enhance the quality of care delivered to this vulnerable patient population.
PMID:
42315459
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.
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