Adrenal Carcinoma Laterality is of Limited Clinical Significance: A National Perspective.

Authors

Mohammad H Hussein, Peter P Issa, Tessa R Lavorgna, Chad P Issa, Charlotte Pecot, Manal S Fawzy, Eman A Toraih

Published in

Cancer investigation. Pages 1-11. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

The clinical implication of adrenal cancer laterality is not well investigated. This retrospective study used the National Cancer Database, including 3962 patients with primary adrenal malignancies. Similar analyses of patients with adrenal cancer were retrieved from the cBioPortal/The Cancer Genome Atlas to validate our findings. Left-sidedness was associated with larger tumor size and distant metastasis, while right-sided tumors displayed LN metastasis more often. There was no difference in survival between the two groups. Analysis of differential genomic and transcriptomic/proteomic effects between right/left adrenal carcinomas was found to be similar. Our analysis highlighted the limited clinical importance of adrenal carcinoma laterality.

PMID:
42318686
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.