Authors
Alaa Naiem Zaro, Salar Nael Sajadieh, Ansam Khaled Doudin, Salem K Qupp, Laith Elayan, Ola Abu Laban, Marwan Qabaja, Amaal Alamleh
Published in
Frontiers in oncology. Volume 16. Pages 1834539. Epub Jun 03, 2026.
Abstract
Epithelioid Hemangioendothelioma (EHE) is a rare malignant vascular neoplasm with an unpredictable clinical behavior and often delayed diagnosis. The malignancy arises from many anatomical sites, with the liver being the most common primary site. This report portrays a young patient who presented atypically with a multifocal hepatic epithelioid hemangioendothelioma (HEHE) and highlights the challenges faced during the diagnosis and management of such rare malignancies.
A 28-year-old male patient from Palestine presented with progressive headache associated with constitutional symptoms. Diagnostic imaging revealed disseminated disease throughout the body. CT-guided liver biopsy confirmed neoplastic cells arranged in small nests and individually, some of which showed intracytoplasmic vacuoles within a hyalinized stroma. Immunohistochemistry was positive for CD31, CD34 and FLI-1, supporting the endothelial origin. Metastatic HEHE was established; a biological treatment plan with Pazopanib (Votrient) was initiated, and the patient was followed for 4 years.
During the follow-up period, serial imaging revealed no significant regression or progression of the lesions, indicating stable disease with the treatment used.
The case emphasizes the clinical intricacy of HEHE, given its rarity, the lack of standardized treatment guidelines, and the tumor's unpredictable course. Specifically, this case illustrates these challenges within the Palestinian healthcare system.
PMID:
42318483
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 5
- Comments 0