Reconsidering Surgical Strategy in the Era of Neoadjuvant Immunotherapy for Head and Neck Cancer.

Authors

Andrea Migliorelli, Andrea Sacchetto, Snehal Patel

Published in

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

Neoadjuvant immunotherapy is increasingly incorporated into the management of resectable locally advanced mucosal head and neck squamous cell carcinoma, raising questions about its impact on surgical decision-making. Despite encouraging trial data, limitations in response assessment and evidence of heterogeneous tumor regression challenge the use of treatment response to guide surgical de-escalation. This commentary highlights current uncertainties and emphasizes the need for prospective evidence before response-adapted surgical strategies can be safely implemented.

PMID:
42319383
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.

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