MASLD in PLWH on ART: Predominance of Metabolic Risk Factors and Insights From Novel Biomarkers-A Cross-Sectional Study in Wrocław, Poland.

Authors

Michał Biały, Małgorzata Inglot

Published in

Journal of the International Association of Providers of AIDS Care. Volume 25. Pages 23259582261436955. Epub Jun 19, 2026.

Abstract

BackgroundMASLD (NAFLD) is the most common chronic hepatopathy and has a rising prevalence in PLWH, with etiological factors being interplay of HIV-specific with general ones.MethodsWe conducted a cross-sectional study (n = 93). Patients were assessed in an outpatient clinic in Poland (April-October 2021) using clinical, metabolic data, irisin, CK-18, adiponectin, and leptin. Noninvasive formulas were used to assess the MASLD risk biochemically.ResultsNo statistically relevant differences in MASLD-related scores among different ART regimens were found, with weak correlations were found between CD4 count and NAFLD-LFS (R < .3), and ART duration with non-HDL-C (R = -.22) and NFS (R = .23). Lifetime weight amplitude showed relationship with biochemical MASLD-related formulas and hepatitis (P = .037); among the biomarkers, leptin exhibited several correlations, strongest with HSI (R = .56) and BMI (R = .53).ConclusionsMASLD corresponded more with general than with ART-related factors. Leptin may value when evaluating MASLD risk.

PMID:
42319008
Bibliographic data and abstract were imported from PubMed on 19 Jun 2026.

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