Decoding nucleic acid modification regulatory networks: A key to cancer intervention and treatment.

Authors

Qi Sun, Yunxuan Shi, Yadong Guo, Xiaojing Wang, Fu Zhao, Ziwei Zhang, Aimin Jiang, Zengkan Du, Zhijie Zhao

Published in

Physics of life reviews. Volume 58. Pages 54-107. Jun 04, 2026. Epub Jun 04, 2026.

Abstract

Nucleic acid modification constitutes a pivotal regulatory mechanism in cancer, influencing the entire process of tumor development, diagnosis, treatment, and prognosis. This review delineates the role of diverse chemical modifications-including methylation, demethylation, N6-methyladenosine, and 5-methylcytosine-in governing genomic stability and cellular dysfunction across DNA, coding RNA, and non-coding RNA levels. The research paradigm of nucleic acid modification in cancer is transitioning from static modification maps to dynamic, interconnected modification networks. Moreover, the crosstalk between nucleic acid modifications and nucleic acid processing further intensifies epigenetic remodeling and oncogenic risk. Elucidating the fundamental mechanisms underlying these modifications will provide critical insights into their overarching significance in cancer initiation and maintenance, while offering promising diagnostic and therapeutic targets for precise targeted treatment of cancer at the nucleic acid level.

PMID:
42320194
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.