Prediction of tumor radiation absorbed dose in radionuclide therapy based on the mean standardized uptake value from PET imaging.

Authors

José Willegaignon, Marcelo Tatit Sapienza

Published in

Nuclear medicine communications. Jun 22, 2026. Epub Jun 22, 2026.

Abstract

Accurate estimation of tumor absorbed dose is essential for effective disease control in radionuclide therapy, but routine dosimetry is often limited by the need for multiple posttherapy imaging acquisitions. This study aimed to develop a simplified method to predict tumor absorbed doses in radionuclide therapy using pretherapy PET standardized uptake value (SUV) measurements. Tumor absorbed doses were estimated using the medical internal radiation dose formalism, PET SUVmean, and radionuclide physical and effective half-lives, assuming comparable tumor uptake between diagnostic and therapeutic radiopharmaceuticals. A mathematical equation was derived to facilitate tumor dose estimation. For representative clinically administered activities, tumor absorbed doses per unit SUVmean were 1.84 ± 0.22, 1.07 ± 0.13, 0.58 ± 0.07, and 0.10 ± 0.01 Gy for the 68Ga/90Y, 124I/131I, 68Ga/177Lu, and 68Ga/225Ac theranostic pairs, respectively. Tumor absorbed dose estimation showed a strong dependence on SUVmean and effective half-life, with good agreement between estimated values and previously reported dosimetric results. Although this simplified model does not replace full patient-specific dosimetry, it may provide a practical approach for pretherapy dose prediction. Further studies are required to validate and refine the proposed model.

PMID:
42319803
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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