Late cerebrospinal fluid shunt infections: a Hydrocephalus Clinical Research Network study.

Authors

David S Hersh, Hailey Jensen, Ron W Reeder, Nichol Nunn, Todd C Hankinson, Susan Staulcup, Jason S Hauptman, Albert M Isaacs, Eric M Jackson, Sydney White, Abhaya V Kulkarni, Thiemo F Dinger, Jonathan A Pindrik, Ian F Pollack, Destiney Davis, Jessica Becerra, Vijay M Ravindra, Jay Riva-Cambrin, Ruksana Rashid, Brandon G Rocque, Andrew T Hale, Tamara D Simon, Jennifer M Strahle, Farrell Landwehr, Mandeep S Tamber, Annika Weir, John C Wellons, Breanne Reisen, William E Whitehead, John R W Kestle

Published in

Journal of neurosurgery. Pediatrics. Pages 1-11. Jun 19, 2026. Epub Jun 19, 2026.

Abstract

Infection is a significant complication of CSF shunt surgery, with most infections occurring early in the postoperative course. While standardized perioperative protocols have successfully reduced early infections, the epidemiology, risk factors, and clinical patterns of late shunt infections are poorly characterized. This study aimed to determine the incidence, risk factors, clinical features, and outcomes of late shunt infections in a large, multicenter pediatric cohort.
The Hydrocephalus Clinical Research Network (HCRN) Core Data Project was queried for all CSF shunt procedures performed between November 2016 and June 2023 in patients younger than 18 years. Each shunt surgery was treated as an index surgery, defined as the starting point for subsequent infection surveillance. Shunt surgeries were assigned to one of the following categories: no infection, early infection (≤ 6 months after the surgery), or late infection (> 6 months after the surgery). Demographic, operative, and clinical features of early versus late infections were compared, and Cox proportional hazards models were developed to assess shunt survival following early versus late infections.
Of 6698 shunt procedures, 285 (4.3%) were followed by early infections and 58 (0.9%) by late infections. Late infections accounted for 16.9% of all shunt infections. Late infections were significantly more likely than early infections to be associated with abdominal pseudocysts (24.1% vs 3.5%, p < 0.001) and less likely to be diagnosed via CSF culture (53.4% vs 78.6%, p < 0.001). Clinical events that took place between the shunt surgery and the late infection included abdominal surgeries (21.4%), shunt taps (23.2%), bacteremia (9.1%), and nonoperative abdominal processes requiring hospitalization (19.6%). Vancomycin was administered less frequently in the late infection group (62.1% vs 85.3%, p < 0.001), and shunts were less likely to be initially treated with complete shunt removal (65.5% vs 88.4%, p < 0.001) and more likely to be initially managed with externalization of the distal catheter alone (34.5% vs 11.6%, p < 0.001). Shunt survival after infection did not differ significantly between early and late infections.
Late CSF shunt infections are uncommon but clinically distinct from early infections and are often associated with heterogeneous secondary exposures not addressed by perioperative protocols. These findings highlight the need for long-term surveillance in patients with shunts, tailored diagnostic strategies, and expanded infection tracking efforts.

PMID:
42320054
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.

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