Authors
Paula Marrero-Fernández, Ujué Fresán, Siobhan Nicaudie, Noelia Rodrigo Huecas, Muthanna Abusaada, Gabriele Bertotti, Alberto Roldán-Ruiz, Miguel López-Moreno
Published in
Nutrition (Burbank, Los Angeles County, Calif.). Volume 150. Pages 113303. May 25, 2026. Epub May 25, 2026.
Abstract
Fibromyalgia (FM) is associated with adverse cardiometabolic profiles and reduced quality of life. Although plant-based dietary patterns have shown cardiovascular benefits, their effects in FM remain unclear. This randomized, parallel-arm controlled trial evaluated the effect of a vegan Mediterranean diet (VegMedDiet) compared with a traditional Mediterranean diet (MedDiet) on low-density lipoprotein cholesterol (LDL-C) and FM-related outcomes.
Twenty-two women with FM were assigned to follow either a VegMedDiet (n = 11) or a MedDiet (n = 11) for 6 weeks. Diets were isocaloric and matched for macronutrient distribution.
The primary outcome was change in LDL-C; secondary outcomes included other cardiometabolic markers, body composition, and FM-related symptoms and were considered exploratory. Outcomes were analyzed using linear mixed-effects models accounting for repeated measures. Compared with the MedDiet, the VegMedDiet produced greater reductions in LDL-C (estimated mean difference -21.2 mg/dL; 95% CI: -38.3 to -4.08) and triglycerides (-27.4 mg/dL; 95% CI: -52.1 to -2.73). Additionally, a significantly greater reduction was observed in the FIQ pain item (estimated mean difference -1.88; 95% CI: -2.99 to -0.77; P = 0.002).
These findings suggest that a VegMedDiet may contribute to short-term improvements in cardiometabolic risk markers and FM-related symptoms compared with a MedDiet, supporting its potential role as a dietary strategy in individuals with FM.
PMID:
42320093
Bibliographic data and abstract were imported from PubMed on 20 Jun 2026.
Read full publication at:
Please sign in
to see all details.
Advertisement
Stats
- Recommendations n/a n/a positive of 0 vote(s)
- Views 2
- Comments 0